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DeCS
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Descriptor English:
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Multidrug Resistance-Associated Proteins
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Descriptor Spanish:
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Proteínas Asociadas a Resistencia a Múltiples Medicamentos
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Descriptor Portuguese:
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Proteínas Associadas à Resistência a Múltiplos Medicamentos
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Synonyms English:
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ATP Binding Cassette, Sub Family C Proteins
ATP-Binding Cassette, Sub-Family C Proteins
MOAT Protein
Multidrug Resistance Associated Protein
Multidrug Resistance Associated Proteins
Multidrug Resistance-Associated Protein
Multispecific Organic Anion Transport Proteins
Multispecific Organic Anion Transporter
Resistance-Associated Protein, Multidrug
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Tree Number:
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D12.776.157.530.100.304
D12.776.157.530.450.074.500.500.500
D12.776.543.585.100.304
D12.776.543.585.450.074.500.500.500
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Definition English:
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A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins. |
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See Related English:
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ATP Binding Cassette Transporter, Subfamily B
Drug Resistance, Multiple
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History Note English:
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2002; use MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS (NM) 1994-2001; for MOAT PROTEIN & MULTISPECIFIC ORGANIC ANION TRANSPORTER use ANION TRANSPORT PROTEINS 1995-2001
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Allowable Qualifiers English:
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Record Number:
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36147
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Unique Identifier:
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D027425
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Occurrence in VHL:
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Similar:
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DeCS
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